FRANCIS BLANCHE,YVES BAUDAT,TARIK DABDOUBI,ANNE-MARIE LEFEBVRE,MAGALI MATHIEU,ANA MERINO-FRIGO,MANOEL NUNES,BÉATRICE CAMERON
申请号：
DO2015000162
公开号：
DOP2015000162A
申请日:
2015.06.26
申请国别(地区):
DO
年份:
2015
代理人:
摘要：
The antibodies provided are specifically bound to human plasma membrane No. 1 (lamp1) and protective proteins related to secretory mumps and immunococci, including composite antibodies or binding to growth inhibitors. Pharmaceutical ingredients are also provided, including the invention of antigens or immunococci and antibodies or immunococci for the treatment of anthrax.Therefore, as the lamp1 antibody, the isolated nucleic acid, vectors and human feeding cells form a sequence, code these antibodies, and use this antibody as a diagnostic tool. In addition, the application also provides evidence of amplification or gain of lamp1 cancer cells, so as to determine whether patients with CCER are likely to receive anti lamp1 treatment. Therefore, a method of patient selection in vitro is proposed, which includes the determination in a biological sample of a patient with cancer causing cellsIf the patient carries the profit of lamp1 gene replication number, the patient is selected according to the profit of lamp1 gene replication number. In addition, an anti lamp1 therapeutic agent is also provided for the treatment of a patient's disease, who has a benefit in the number of lamp1 genes in cancer cells.SE PROPORCIONAN ANTICUERPOS QUE SE UNEN ESPECÍFICAMENTE A LAS PROTEÍNAS PROTEÍNA ASOCIADA A LA MEMBRANA LISOSOMAL 1 (LAMP1) HUMANA Y DE MACACA FASCICULARIS E INMUNOCONJUGADOS QUE COMPRENDEN DICHOS ANTICUERPOS CONJUGADOS O UNIDOS A UN AGENTE INHIBIDOR DEL CRECIMIENTO. TAMBIÉN SE PROPORCIONAN COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN ANTICUERPOS O INMUNOCONJUGADOS DE LA INVENCIÓN Y USO DE LOS ANTICUERPOS O INMUNOCONJUGADOS PARA EL TRATAMIENTO DEL CÁNCER., ASÍ COMO ANTICUERPOS LAMP1, ÁCIDOS NUCLEICOS AISLADOS, VECTORES Y CÉLULAS HUÉSPED QUE COMPRENDEN UNA SECUENCIA QUE CODIFICA DICHOS ANTICUERPOS Y EL USO DE DICHO ANTICUERPO COMO UNA HERRAMIENTA DE DIAGNÓSTICO. LA SOLICITUD PROPORCIONA ADEMÁS LA DETECCIÓN DE LA AMPLIFICACIÓN O GANANCIA DEL GEN LAMP1 EN CÉLULAS CANCEROSAS QUE
