БАКСТЕР ИНТЕРНЭШНЛ ИНК. (US);БАКСТЕР ХЕЛТКЭАР СА (CH)
发明人:
МАККОЙ Джил (US),ДУАЙЕР Джозеф Ф. (US),ЯН Цзыпин (US)
申请号：
RU2014121232/15
公开号：
RU2014121232A
申请日:
2012.10.25
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. Hemostatic composition containing gelatin in the form of particles suitable for use for hemostasis, characterized in that the composition is presented in the form of a paste containing from 15.0 to 19.5 wt. % crosslinked gelatin, preferably from 16.0 to 19.5 wt. %, from 16.5 to 19.5 wt. %, from 17.0 to 18.5 wt. % or from 17.5 to 18.5 wt. %, more preferably from 16.5 to 19.0 wt. % or from 16.8 to 17.8 wt. %, particularly preferably from 16.5 to 17.5 wt. % and from 0.5 to 5.0 wt. %, preferably from 1.0 to 5.0 wt. %, preferably from 2.0 to 4.5 wt. %, more preferably from 1.5 to 5.0 wt. %, most preferably about 1.5 wt. % of the substance facilitating its extrusion, where the substance facilitating its extrusion is albumin. 2. The hemostatic composition according to claim 1, wherein the crosslinked gelatin is gelatin crosslinked by glutaraldehyde or gelatin crosslinked by genipin. 3. The hemostatic composition according to claim 2, wherein the crosslinked gelatin is type B.4 gelatin. A hemostatic composition according to claim 1, wherein the crosslinked gelatin is in the form of a granular substance. The hemostatic composition according to claim 4, wherein the particle sizes of the crosslinked gelatin are from 100 to 1000 microns, preferably from 200 to 800 microns, particularly preferably from 350 to 550 microns. The hemostatic composition according to claim 1, wherein the composition contains thrombin, preferably from 10 to 1000 IU thrombin / ml, in particular from 250 to 700 IU thrombin / ml. Hemostatic composition according to any one of paragraphs. 1-6 for use in the treatment of lesions selected from the group consisting of wounds, bleeding, damaged tissue, bleeding tissue and / or bone defects. 8. The use of a hemostatic composition according to any one of paragraphs. 1-6 in the damaged area in the manufacture of a medicam1. Гемостатическая композиция, содержащая желатин в форме частиц, подходящей для применения с целью гемостаза, отличающаяся тем, что композиц
