Brian Dean Schreiber,Gianfranco Fornasini,Nadejda Soukhareva,Santosh Kumar Ramamurthy
申请号：
US16449109
公开号：
US20190365874A1
申请日:
2019.06.21
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided are Adenosine Deaminase (ADA), or a polypeptides or peptides having an ADA activity, or an ADA conjugate, pharmaceutical compositions and formulations, products of manufacture and kits, and methods containing them for the prevention and treatment of a scleroderma-associated vasculopathy, in particular proliferative obliterative vasculopathy, progressive obliterative vasculopathy or an idiopathic obliterative vasculopathy and/or preventing or decreasing the progression of scleroderma, wherein optionally the scleroderma comprises a local scleroderma or a diffuse, or a systemic scleroderma.
