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TREATMENT OF SOLID TUMOURS
专利权人:
VIVOLUX AB
发明人:
LINDER, STIG,FRYKNAS, MARTEN,LARSSON, ROLF
申请号:
CA2830081
公开号:
CA2830081A1
申请日:
2012.03.14
申请国别(地区):
CA
年份:
2012
代理人:
摘要:
A cell permeable iron chelator, optionally in combination with an autophagy inhibiting agent, is used for treating a solid cancer tumour in a person. A preferred chelator is an alkyl substituted N-(1-pyridine-2-yl-methylidene)-N-(9H-1,3,4,9-tetraaza-fluoren-2-yl)-hydrazine. A preferred autophagy inhibiting agent is chloroquine. Also disclosed is a pharmaceutical composition comprising iron chelator, pharmaceutically acceptable carrier and, optionally, autophagy inhibiting agent and a method of treating cancer by administering cancer combating-effective amount(s) of the iron chelator or the combination of iron chelator and autophagy inhibiting agent.
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