A caster mounting assembly for mounting a caster wheel on a wheelchair frame includes a mounting body defining a barrel portion to be fixed relative to the wheelchair frame and a rotatable body within the barrel portion that supports the caster wheel thereon for rotation relative to the rotatable body about an upright caster axis. The caster axis is arranged for rotation together with the rotatable body relative to the mounting body. A locking member is slidable within a channel in the mounting body and includes teeth in meshing engagement with corresponding teeth on the rotatable body. One or more positioning screws permit the locking member to be controllably displaced between longitudinally different locking positions within the channel corresponding to different angular orientations of the caster wheel axis.