As for long-cherished desire formula (i):(In formula, as for R1, R2, R3, R4 and m as defined in this bill, is.)Chemical compound or that medicine approved possible salt, the solvent dishes dressed with sauce, the salt or combination of the professional drug and the professional drug are disclosed. Using the composition and this kind of chemical compound and the composition which contain this kind of chemical compound, it discloses also the method of remedying the sick condition and the disease.本願は式(I):(式中、R1、R2、R3、R4及びmは本明細書に定義する通りである。)の化合物又はその医薬的に許容可能な塩、溶媒和物、プロドラッグ、プロドラッグの塩もしくは組合せを開示する。このような化合物を含有する組成物と、このような化合物及び組成物を使用して病態及び疾患を治療する方法も開示する。