The invention provides a method and/or composition for the treatment of bone cancer including primary bone cancer and secondary bone cancer, breast cancer, skin cancer, nasopharyngeal carcinoma, oral cancer, vulva cancer, prostate cancer, cervical cancer, melanoma including melanocarcinoma by percutaneous and/or transmucosal administration of the interferon. Further, the invention provides a method and/or composition for the treatment of skin, subcutaneous, mucosal and/or submucosal primary cancer and cancer metastatic lesions by percutaneous and/or transmucosal administration of the interferon, especially a method and/or composition for the treatment of bone cancer pain including pain resulted by secondary bone cancer.本發明提供通過干擾素的經皮和/或經粘膜給藥用於治療骨癌包括原發性骨癌和繼發性骨癌、乳腺癌、皮膚癌、鼻咽癌、口癌、外陰癌、前列腺癌、宮頸癌、黑色素瘤包括黑色素癌的方法和/或組合物。此外，本發明提供了通過干擾素的經皮和/或經粘膜給藥用於治療皮膚、皮下、粘膜、和/或粘膜下原發癌及癌症轉移病灶的方法和/或組合物，尤其是用於治療骨癌疼痛包括繼發性骨癌所引起疼痛的方法和/或組合物。
