President and Fellows of Harvard College;Massachusetts Institute of Technology
发明人:
R. John Collier,Isaac Chiu,Bradley L. Pentelute
申请号：
US15755543
公开号：
US10704035B2
申请日:
2016.08.26
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Embodied herein are engineered fusion proteins that bind and target nociceptor neurons, compositions comprising these engineered fusion proteins, and methods for treatment of pain using these engineered fusion proteins or compositions containing the engineered fusion proteins. The engineered fusion proteins contain domains derived from protein toxins such as the anthrax toxin, clostridial botulinum family of toxins, disulphide-containing toxins, and AB component type toxins.
