TECHNOPHAGE; INVESTIGAçÃO E DESENVOLVIMENTO EM BIOTECNOLOGIA; SA
发明人:
Frederico Nuno Castanheira Aires da Silva,Sofia Volker Cörte-Real,Rui Pedro da Silva Albuquerque e Freitas,Sara Ferreira Llorente Grancho Lourenço
申请号：
US14346151
公开号：
US09399678B2
申请日:
2012.09.19
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to polypeptides comprising one or more antibody single domains, or antigen-binding fragments thereof, directed against Tumor Necrosis Factor-alpha, in particular, two light chain variable domains in dimeric form, where the dimer has high solubility. It also relates to methods of using anti-Tumor Necrosis Factor-alpha polypeptides in treating inflammatory disorders, including rheumatoid arthritis. Compositions and methods for enhancing therapeutic potential of anti-Tumor Necrosis Factor-alpha polypeptides are provided, including linking the polypeptide to an albumin-binding domain and/or de-immunizing the polypeptide, to provide therapeutic agents with good solubility, enhanced serum half-life, and/or reduced immunogenicity, while substantially maintaining the specific binding properties of the anti-Tumor Necrosis Factor-alpha polypeptides.
