The naphthalene carboxamide derivatives, the preparation methods and the uses thereof are provided. The structure thereof is shown as the formula (I), wherein the definitions of R 1 , R 2 , R 3 , R 4 and Z are the same to those described in the description. The compounds have the protein kinase inhibition activities and the histone deacetylase inhibition activities simultaneously, and can be used for treating diseases related to protein kinase activity abnormity or histone deacetylase activity abnormity, including inflammation, autoimmune diseases, cancer, nervous system diseases and neurodegenerative diseases, cardiovascular diseases, metabolic diseases, allergies asthma, and hormone-related diseases.
