CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;INSTITUT PASTEUR
发明人:
TANGY, FREDERIC,SIMON-LORIERE, ETIENNE
申请号：
CA3064322
公开号：
CA3064322A1
申请日:
2018.06.06
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention relates to recombinant measles virus expressing Zikavirus proteins and their applications, inparticular in inducing preventive protection against Zika virus. The presentinvention is directed to recombinant measles virus (MV)expressing at least (i) the precursor of membrane (prM) protein of a Zikavirus (ZIKV), and the envelope (E) protein of a ZIKV or atruncated version thereof, or (ii) the E protein of a ZIKVor a truncatedversion thereof, and concerns recombinant infectious particles ofsaid MV-ZIKV able to replicate in a host after an administration, and alsoVirus Like Particles (VLPs) that contain these ZIKV proteinsat their surface. The present invention provides means, in particular nucleicacids, vectors, cells and rescue systems to produce theserecombinant infectious particles and VLPs. The present invention also relatesto the use of these recombinant infectious particles and/or VLPs, in particular under the form of a composition, more particularly in avaccine formulation, for the prevention of an infectionby ZIKV or for the preventive protection against clinical outcomes of ZIKVinfection.
