A dual chamber syringe comprising a first barrel defining a first chamber (12) for holding a first composition, the first chamber having at least one side wall and a distal end wall defining a dispensing nozzle (22). A second barrel defining a second chamber (14) for holding a second composition, the second chamber having at least one side wall (14) and a distal end wall, an annular seal at the distal end of the second barrel, and the at least one side wall of the second chamber defining at least one orifice proximal to the seal； and a plunger operable to drive the second barrel into the first chamber to displace the first composition out of the first chamber through the nozzle, and to bring the annular seal of the second barrel into contact with the distal end wall of the first chamber, thereby to deform the seal and permit fluid communication between each orifice in the second barrel and each flow channel, wherein the plunger is subsequently moveable into the second chamber to displace the second composition out of the second chamber through each orifice and flow channel to the nozzle.
