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3D Differentiation method of securing large amount of cells by chopping target cell enriched 3D organoids prepared from human pluripotent stem cells
专利权人:
IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY);한양대학교 산학협력단
发明人:
LEE SANG HUN,이상훈,CHANG MI YOON,장미윤,KIM SEUNG WON,김성원,WOO HYE JI,우혜지
申请号:
KR1020190128602
公开号:
KR1020200043297A
申请日:
2019.10.16
申请国别(地区):
KR
年份:
2020
代理人:
摘要:
The present invention relates to a method of securing a large amount of finally differentiated cells by patterning 3D organoids produced from human pluripotent stem cells, disassembling the same, culturing the corresponding stem cells or progenitor cells, and inducing differentiation. Cells secured in large quantities are expected to be very useful for the cell therapy or the screening of therapeutic drugs by exhibiting significantly superior effects in terms of reproducibility, stability, and functionality compared to cells differentiated by conventional differentiation methods.본 발명은 인간 만능 줄기세포로부터 제작된 3D 오가노이드를 패턴화하고 해체하여 해당 줄기세포 또는 전구세포를 배양하고 분화를 유도하여 최종 분화된 세포를 다량 확보하는 방법에 관한 것으로, 다량 확보된 세포는 기존 분화방법에 의해 분화된 세포에 비해 재현성, 안정성, 기능성 면에서 현저히 우수한 효과를 나타냄으로써 세포치료제나 치료 약물 스크리닝에 매우 유용하리라 기대된다.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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