Provided is a theranostic bubble preparation which makes it possible diagnose and treat a tissue of interest through irradiation with diagnostic ultrasound and irradiation with low intensity therapeutic ultrasound. The theranostic bubble preparation contains bubbles each including a coating of lipid and a gas encapsulated in an inner cavity defined by the coating. The lipid forming the coating is an anionic lipid including distearoylphosphatidylcholine (DSPC), distearoylphosphatidylglycerol (DSPG), and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG2000). The gas and mixed gas include perfluoropropane or perfluorobutane.
