MUTATED ANTHRAX TOXIN PROTECTIVE ANTIGEN PROTEINS THAT SPECIFICALLY TARGET CELLS CONTAINING HIGH AMOUNTS OF CELL-SURFACE METALLOPROTEINASES OR PLASMINOGEN ACTIVATOR RECEPTORS
THE GOVERNMENT OF THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SE CRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
LEPPLA, STEPHEN H.,LIU, SHI-HUI,NETZEL-ARNETT, SARAH,BIRKEDAL-HANSEN, HENNING,BUGGE, THOMAS
申请号：
CA2385122
公开号：
CA2385122C
申请日:
2000.09.22
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention provides methods of specifically targeting compounds tocells overexpressing matrix metalloproteinases, plasminogen activators, orplasminogen activator receptors, by administering a compound and a mutantprotective antigen protein comprising a matrix metalloproteinase or aplasminogen activator-recognized cleavage site in place of the nativeprotective antigen furin-recognized cleavage site, wherein the mutantprotective antigen is cleaved by a matrix metalloproteinase or a plasminogenactivator overexpressed by the cell, thereby translocating into the cell acompound comprising a lethal factor polypeptide comprising a protectiveantigen binding site.
