Methods and Compositions of Improved Modified siRNA

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专利权人:

发明人:

Xian-bin Yang

申请号：

US14645351

公开号：

US20150322431A1

申请日:

2015.03.11

申请国别(地区):

US

年份:

2015

代理人:

摘要：

Chemically modified small interfering RNAs (siRNAs) that include both phosphorodithioate modifications (PS2-RNA) and 2′-O-methyl modifications (MePS2) provide improved RNA silencing. Specific chemically modified siRNA that show enhanced silencing of RNAs involved in resistance to chemotherapeutic agents are provided.

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