ARTHUR L. HEWITT,CAMERON SZAKACS,CHRISTOPHER CIOFFI,GERRY ROWSE,MICHAEL J. ROBERTS,WILLIAM SCHWIETERMAN
申请号：
BR112014018851
公开号：
BR112014018851A2
申请日:
2013.01.30
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The present invention provides methods and systems for reducing falls in patients that are recurrent fallers. Specifically, the compositions, systems, and methods can relate to Parkinson's disease patients, particularly such patients that are suffering from neurogenic orthostatic hypotension. The compositions, systems, and methods comprise the use of droxidopa, optionally in combination with a further active agent. Administration of droxidopa has been found to reduce the mean number of falls per patient per week, as well as provide improvements in the patient's Hoehn and Yahr rating scale score, which is indicative of improvements in postural stability, and provide improvements in the patient's Unified Parkinson's disease Rating Scale score, which is indicative of improvements in the severity of motor and/or non-motor symptoms of Parkinson's disease.
