Jeffrey Miller;Vipula K. Shukla;Ryan C. Blue;Fyodor Urnov;Jon C. Mitchell;Nicole L. Arnold;Qihua C. Cai;Joseph F. Petolino;Lisa W. Baker;Robbi J. Garrison;Sarah E. Worden
发明人:
Qihua C. Cai,Vipula K. Shukla,Joseph F. Petolino,Lisa W. Baker,Robbi J. Garrison,Ryan C. Blue,Jon C. Mitchell,Nicole L. Arnold,Sarah E. Worden,Jeffrey Miller,Fyodor Urnov
申请号:
US12286668
公开号:
US08921112B2
申请日:
2008.10.01
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.