A polymeric matrix for delivery of an HMG CoA reductase inhibitor such as a statin to tissue such as cardiac tissue in need thereof for the treatment or prevention of a disease or defect such as atrial fibrillation has been developed. In the preferred embodiment a statin is delivered by means of a patch sutured to cardiac tissue at the time of cardiothoracic surgery. In the most preferred embodiment the patch is a biodegradable material providing controlled or sustained release over a prolonged period of time such as a week. Suitable materials include extracellular matrix or other biodegradable hydrogels or polymeric materials providing sustained or controlled release of statin at the site of application.
