Compounds of the formula II:wherein R2is the side chain of leucine, isoleucine, cyclohexylglycine, O-methyl threonine, 4-fluoroleucine or 3-methoxyvaline； R3is H, methyl or F； Rq is trifluoromethyl and Rq' is H or Rq and Rq' define keto； Q is a p-(C1-C6alkylsulphonyl)phenyl- or an optionally substitued 4-(C1-C6alkyl)piperazin-1-yl-thiazol-4-yl- moiety have utility in the treatment of disorders characterized by inappropriate expression or activation of cathepsin K, such as osteoporosis, osteoarthritis, heumatoid arthritis or bone metastases.本發明提供一種式II之化合物：其中R2係白胺酸、異白胺酸、環己基甘胺酸、O－甲基蘇胺酸、4－氟白胺酸或3－甲氧基纈胺酸之側鏈；R3係H、甲基或F；Rq係三氟甲基且Rq'係H或Rq與Rq'一起之定義為酮；Q係對－(C1－C6烷基磺醯基)苯基－或視情況經取代之4－(C1－C6烷基)哌嗪－1－基－噻唑－4－基－部分，該等化合物可用於治療以組織蛋白酶K之不適當表現或活化為特徵之病症，例如，骨質疏鬆症、骨關節炎、類風濕性關節炎或骨轉移。
