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Compositions and Methods for Altering Amyloid Precursor Protein (APP) Processing
专利权人:
DREXEL UNIVERSITY
发明人:
Olimpia MEUCCI,Renato BRANDIMARTI
申请号:
US16380719
公开号:
US20190309026A1
申请日:
2019.04.10
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The present invention relates to the discovery of compositions and methods for altering Amyloid Precursor Protein (APP) processing. Alerting APP processing is aids the treatment of neuropathological disorders such as those associated with HIV infection and Alzheimer's disease (AD). The invention includes fusion protein constructs that include an effector protein and an HSV US9 protein or functionally active fragment thereof that reduce the amount of amyloid β-protein produced in a cell.
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