A method of diagnosing an eye disease having an element of age-related retinopathy with acquired choroidal abnormalities in a subject is described. The method comprises providing a sample to be tested obtained from the subject, determining the level of expression of at least one biomarker in the sample, determining a control level of expression of said at least one biomarker in a control sample obtained from a subject not afflicted with the eye disease, comparing said level of expression with said control level of expression of said at least one biomarker, wherein a level of expression of said at least one biomarker in said sample that is higher than said control level of expression of said at least one biomarker in said control sample is indicative of the presence of said eye disease, and wherein a level of expression of said at least one biomarker in said sample that is equal to or lower than said control level of expression of said at least one biomarker in said control sample is indicative of the absence of said eye disease, and wherein said at least one biomarker is selected from IL-33, regulatory T-cells, and/or T-helper-2-like regulatory T-cells.
