The invention provides a synthetic polypeptide of Formula I': or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.本發明提供式I'之合成多肽，或其醯胺、酯或鹽，其中X1、X2、X3、X4、X5、X6、X7、X8、X9、X10、X11、X12及X13係如本文中定義。該等多肽係APJ受體之激動劑。本發明亦係關於製造本發明之多肽之方法及其治療用途，例如治療或預防急性失代償性心臟衰竭(ADHF)、慢性心臟衰竭、肺性高血壓、心房震顫、布魯格達氏症候群(Brugada syndrome)、心室性心博過速、動脈粥樣硬化、高血壓、再狹窄、局部缺血性心血管疾病、心肌病、心臟纖維化、心律不整、水滯留、糖尿病(包括妊娠糖尿病)、肥胖症、周邊動脈病、腦血管意外、暫時性腦缺血、創傷性腦損傷、肌肉萎縮性脊髓側索硬化症、燒傷(包括曬傷)及子癇前症。本發明進一步提供藥理活性劑之組合及醫藥組合物。
