The invention concerns the application of the fungal organism Pythium oligandrum as a strong mycoparasite in connection with the applicable inorganic or organic carrier of the efficient agens as a preparation for additional fertilization and for protection of plants against the originators of microbial diseases and as a preparation for the elimination of post-harvest losses and losses during storage of commodities coming from plant or animal production, including the preparation for the liquidation of wood-destroying fungi. The application of the preparation for the protection of plants against the originators of microbial diseases can also be performed in the form of aerial spraying.