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XENON BASED DRUG PROTEIN BINDING ASSAY
专利权人:
The Regents of the University of California
发明人:
Gomes Muller,Vassiliou Christophoros,Pines Alex
申请号:
US201715819300
公开号:
US2018149606(A1)
申请日:
2017.11.21
申请国别(地区):
美国
年份:
2018
代理人:
摘要:
Described herein is a technique and method for analyzing the protein binding affinity of a drug. The techniques and methods described herein leverage magnetic resonance techniques such as NMR and MRI to make relaxation measurements of an NMR detectable species. In some embodiments, a rubidium polarizer is used to magnetize 129Xe, which is bubbled into a protein solution. The magnetic decay of the hyperpolarized 129Xe is monitored by measuring the T1 or T2 of 129Xe through NMR spectroscopy.
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中国工程科技知识中心
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