XENON BASED DRUG PROTEIN BINDING ASSAY

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专利权人:

The Regents of the University of California

发明人:

Gomes Muller,Vassiliou Christophoros,Pines Alex

申请号：

US201715819300

公开号：

US2018149606(A1)

申请日:

2017.11.21

申请国别(地区):

美国

年份:

2018

代理人:

摘要：

Described herein is a technique and method for analyzing the protein binding affinity of a drug. The techniques and methods described herein leverage magnetic resonance techniques such as NMR and MRI to make relaxation measurements of an NMR detectable species. In some embodiments, a rubidium polarizer is used to magnetize 129Xe, which is bubbled into a protein solution. The magnetic decay of the hyperpolarized 129Xe is monitored by measuring the T1 or T2 of 129Xe through NMR spectroscopy.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/