The Board of Trustees of The Leland Stanford Junior University
发明人:
MAJETI, Ravindra,GRIFFIN, Emily Piccione
申请号：
EP15829487
公开号：
EP3188758A4
申请日:
2015.08.07
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
SIRPabodies comprise an immunoglobulin variable region, which may specifically bind a tumor antigen, viral antigen, etc., fused to a sequence comprising a binding domain of SIRPα. The binding domain of SIRPα comprises at least the N-terminal Ig-like domain of SIRPα, and may further comprise additional SIRPα sequences. The SIRPabodies find use in therapeutic methods that benefit from the combined activity of blocking CD47 activity, and antibody targeting, e.g. in the treatment of cancer, etc. In some specific embodiments, the SIRPabody comprises anti-CD20 activity and a SIRP binding domain anti-CD99 and a SIRP binding domain or anti-TIM3 activity and a SIRP α binding domain.
