The present application provides a Ganoderma Lucidum strain suitable for large-scale liquid fermentation, a method of obtaining a Ganoderma Lucidum strain suitable for large-scale liquid fermentation by mutagenizing and breeding, and use of the strain which is named as Ganoderma Lucidum G2, deposited with China General Microbiological Culture Collection Center under the accession number CGMCC No.3982 on July 20, 2010. The Ganoderma Lucidum strain of the present application is obtained by artificial mutagenizing and breeding, and is suitable for large-scale liquid fermentation. The Ganoderma Lucidum strain of the present application belongs to Ganodermataceae, genus Ganoderma, species red Ganoderma Lucidum. The production of mycelia using the Ganoderma Lucidum strain G2 of the present application is 80~120 times higher as compared with the production of mycelia using wild-type naive Ganoderma Lucidum strain. In addition, the mycelia produced using the Ganoderma Lucidum strain G2 of the pres
