Dvora Teitelbaum;Michael Sela;Rina Aharoni;Ruth Arnon;Masha Fridkis-Hareli;Jack L. Strominger
发明人:
Rina Aharoni,Dvora Teitelbaum,Ruth Arnon,Michael Sela,Masha Fridkis-Hareli,Jack L. Strominger
申请号：
US14188531
公开号：
US20150030560A1
申请日:
2014.02.24
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array； wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides to the mammal.
