COMPOSITIONS AND METHODS FOR SELECTIVE PHAGOCYTOSIS OF HUMAN CANCER CELLS

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专利权人:

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人:

Dennis E. Discher,Kyle R. Spinler,Cory Alvey

申请号：

US15366844

公开号：

US20170151282A1

申请日:

2016.12.01

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The present invention relates to compositions and methods that provide novel therapies in cancer. The invention includes a phagocytic cell modified with a repressor of signal regulatory protein-alpha (SIRPα) and bound to a targeting antibody to enhance phagocytic activity of the phagocytic cell toward tumor tissue. Methods of enhancing phagocytic activity and treating a tumor are also included.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/