The present invention provides, among other things, effective oral formulations based on desazadesferrithiocin polyether (DADFT-PE) analogues, salts and polymorphs thereof, as well as their application for treatment of metal overload, in particular, iron overload, and associated diseases, disorders and conditions.本發明尤其提供基於脫氮雜去鐵硫辛聚醚(DADFT-PE)類似物、其鹽及多晶型物之有效經口調配物以及其用於治療金屬過載、尤其鐵過載,以及相關疾病、病症及病狀的應用。