University College Cardiff Consultants Limited;Katholieke Universiteit Leuven
发明人:
Migliore, Marco,McGuigan, Christopher,Balzarini, Jan
申请号：
AU2007246814
公开号：
AU2007246814B2
申请日:
2007.05.09
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
A compound for use in the treatment or prophylaxis of viral infections such, for example as chicken pox or shingles caused by the Varicella Zoster virus, said compound having the general formula (II): wherein X is O, S, NH or CH, Y is O, S or NH, Z is O, S or CH, R is Calkyl, preferably -alkyl, e.g., -pentyl or -hexyl, and one of R and R is OH, and the other of R and R is a neutral, non-polar amino acid moiety, or a pharmaceutically acceptable salt or hydrate thereof. Said neutral, non-polar amino acid moiety R or R may be (IV): in which R, R, R and R are each independently H or C alkyl. In preferred embodiments, one of R or R is valine, leucine, isoleucine or alanine, particularly valine.
