The Arizona Board of Regents On Behalf of the University of Arizona
发明人:
HURLEY, Laurence,GOKHALE, Vijay,KANG, HyunJin,WU, Kui
申请号：
EP20160871454
公开号：
EP3383841(A1)
申请日:
2016.11.30
申请国别(地区):
欧洲专利局
年份:
2018
代理人:
摘要：
The present invention provides hTERT modulators and methods for producing and using the same. In particular, the present invention provide a compound of the formula as described herein. Some aspects of the invention are based on the characterization of the effect of hTERT core promoter region mutants on the 5-12 G-quadruplex structure and its stability. It is believed that some of the compounds of the invention bind selectively to the G-quadruplex in the hTERT core promoter mutant, which results in reversal of the effect of mutant promoter activation.
