PLATINUM PRODRUGS AND METHODS OF MAKING AND USING THEREOF

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专利权人:

发明人:

Shanta Dhar,Rakesh Pathak

申请号：

US15555693

公开号：

US20180044362A1

申请日:

2016.03.07

申请国别(地区):

US

年份:

2018

代理人:

摘要：

Disclosed herein are prodrugs of platinum containing anticancer agents such as cisplatin that contain an alkylating moiety. Upon administration, the prodrugs release the platinum containing anticancer agent and the alkylating agent, which can form an adduct with DNA or can protect the platinum containing agent from removal. The disclosed prodrugs can be used to treat various cancers, including cisplatin resistant cancers.

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