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超穩胰島素類似物在聚合物熔體中的包囊
专利权人:
CASE WESTERN RESERVE UNIVERSITY
发明人:
WEISS, Michael,POKORSKI, Jon
申请号:
HK18114770
公开号:
HK1255634A1
申请日:
2018.11.20
申请国别(地区):
HK
年份:
2019
代理人:
摘要:
An insulin composition comprises an insulin analogue and polymer blend. The insulin analogue contains cysteine substitutions at positions B4 and A10 (to form cystine B4-A10), and one or more additional substitutions selected from the group consisting of: a connecting domain of 5-11 amino acids between insulin A- and B domains; a non-beta-branched amino-acid substitution at position A8; a non-beta-branched acidic or polar side chain at position A14; a halogenic modification of PheB24 at the ortho position; and substitution of lysine at position B29 by Glu, Ala, Val, Ile, Leu, amino-propionic acid, amino-butryic acid, or Norleucine. The insulin analogue is compatible with a process of manufacture that includes one or more steps within the temperature range 90-120 oC. The encapsulated insulin analogue may optionally contain free PEG or be PEGylated. The insulin analogue-encapsulated polymer blend may be cast as a microneedle patch for topical administration or as micropellets for subcutaneous injection.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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