GALLEY GUIDO,GALLEY Guido,GHELLAMALLAH CEDRIC,GHELLAMALLAH Cedric,NORCROSS ROGER,NORCROSS Roger,PFLIEGER PHILIPPE,PFLIEGER Philippe
申请号:
SI201230279
公开号:
SI2717873T1
申请日:
2012.06.06
申请国别(地区):
SI
年份:
2015
代理人:
摘要:
The invention relates to compounds of formula IA and IB wherein R1, R2, R3, R4 and Z are as defined herein or to a pharmaceutically suitable acid addition salt thereof. Compounds of formulas IA and IB have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1. The compounds can be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinsons disease, neurodegenerative disorders such as Alzheimers disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.