The present invention relates to cyclic preS-derived peptides of HBV which are versatile vehicles for the targeted delivery of compounds to the liver, preferably to hepatocytes, in vitro as well as in vivo. The present invention further relates to conformationally constrained cyclic preS-derived peptides of HBV which are versatile vehicles for the targeted delivery of compounds to the liver, preferably to hepatocytes, in vitro as well as in vivo.The present invention further relates to pharmaceutical compositions comprising at least one cyclic peptide. The present invention further relates to medical uses of said cyclic peptides and the pharmaceutical compositions, such as in the diagnosis, prevention and/or treatment of a liver disease or condition. The present invention further relates to methods for the specific delivery of compound(s) to the liver, methods for the diagnosis, prevention and/or treatment of a liver disease or condition and/or methods for the diagnosis, prevention and/or treatment of a cardiovascular disease.
