Ralph Weissleder,Ching-Hsuan Tung,Umar Mahmood,Lee Josephson,Alexei Bogdanov
申请号：
US10979755
公开号：
US08486373B2
申请日:
2004.11.01
申请国别(地区):
US
年份:
2013
代理人:
摘要：
An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging.
