Valerie A. Kickhoefer,Leonard H. Rome,Kathleen A. Kelly,Cheryl I. Champion
申请号：
US13371260
公开号：
US20120141534A1
申请日:
2012.02.10
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Methods and compositions are provided herein for immunizing a subject against Chlamydial genital infection by administering to the subject an effective amount of a Chlamydial immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. In some aspects, the vault-like-particles are administered to the nasal mucosa. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity at mucosal surfaces while reducing inflammation associated with Chlamydia infection.
