The present invention provides a method for highly effective and uniformly delivering active ingredients into the sites of action of the skin. Besides simultaneously ensuring the active ingredients’ long-term stability, the administering procedure of this preparation is operated easily by patients, and is also an effective method of administering the active ingredients. The technical means solved by this method is a microneedle combination preparation used for skin treatment, wherein the preparation comprises a supporting body, and a plurality of polymeric substance bases formed on said supporting body having in vivo solubility and spinnability. Said base comprises conical or pyramidal microneedle that maintains the target substance. Said target substance is used effectively for the prevention or treatment of skin aging, or it is a substance that can be used for treatment of skin scarring.本發明之課題係提供一種高效率且均勻地將有效成分送達皮膚之作用部位，同時確保有效成分之長期安定性，投予操作容易且對患者的負擔少之製劑及有效成分之投予方法。課題之解決手段係一種皮膚治療用微細針組合型製劑，其具有：支撐體，與在該支撐體上形成之複數個包含具有體內溶解性及可紡性之高分子物質之基劑，且該基劑具有保持目的物質之圓錐狀或角錐狀微細針，該目的物質係用以預防或治療皮膚老化或者治療皮膚瘢痕有效之物質。
