THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ;ADVAXIS, INC.
发明人:
Petit Robert,Wallecha Anu,Patterson Yvonne,Singh Reshma
申请号：
US201515534910
公开号：
US2018153974(A1)
申请日:
2015.12.18
申请国别(地区):
美国
年份:
2018
代理人:
摘要：
The disclosure is directed to compositions comprising an oncolytic virus, chimeric antigen receptor T cells (CAR T cells), a therapeutic or immunomodulating monoclonal antibody, a targeting thymidine kinase inhibitor (TKI), or an adoptively transferred cells incorporating engineered T cell receptors, and a live attenuated recombinant Listeria strain comprising a fusion protein of a Truncated LLO, a truncated ActA or a PEST-sequence peptide fused to a tumor-associated antigen. The disclosure is further directed to methods of treating, protecting against, and inducing an immune response against a tumor, comprising the step of administering the same, with or without an additional radiation therapy treatment.
