BOTELLA, Gabriel Martinez,HARRISON, Boyd L.,ROBICHAUD, Albert Jean,SALITURO, Francesco G.,BERESIS, Richard Thomas
申请号：
EP15862506
公开号：
EP3224269A4
申请日:
2015.11.27
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Described herein are neuroactive steroids of the Formula (II):or a pharmaceutically acceptable salt thereof； wherein A, R<；sup>；1<；/sup>；, R<；sup>；2a<；/sup>；, R<；sup>；2b<；/sup>；, R<；sup>；3a<；/sup>；, R<；sup>；3b<；/sup>；, R<；sup>；4a<；/sup>；, R<；sup>；4b<；/sup>；, R<；sup>；5<；/sup>；, R<；sup>；6<；/sup>；and------are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
