The present invention provides a polypeptide that is rich in leucine and used for preventing and restraining inflammation, and an application of same. The present invention further provides a method for preparing the polypeptide and a pharmaceutical composition containing the polypeptide. The advantage of the polypeptide comprises: small molecular weight, so as to permeate various eye tissue barriers high water solubility, so as to have high dissolubility in neutral tears, aqueous humor and vitreous humor and simple synthesis, so as to have a low preparation cost.
