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METHODES DE MANIPULATION DE DESTINEE CELLULAIRE
专利权人:
THE MCLEAN HOSPITAL CORPORATION
发明人:
KIM, KWANG-SOO
申请号:
CA3052622
公开号:
CA3052622A1
申请日:
2018.02.02
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
Disclosed herein are methods of generating induced pluripotent stem cells. The method involves providing a somatic or non-embryonic cell population, contacting the somatic or non-embryonic cell population with a quantity of at least one reprogramming factor, an agent that downmodulates SIRT2, and/or an agent that upmodulates SIRT1, and culturing the somatic or non-embryonic cells for a period of time sufficient to generate at least one induced pluripotent stem cell. Methods for differentiating a cell by upmodulating SIRT2 and/or downmodulating SIRT1 are also provided herein. Also disclosed are cell lines and pharmaceutical compositions generated by use of the methods.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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