Tong, Ping,Zhou, Deliang,Zhang, Geoff G.Z.,Heemstra, Katherine,Fischer, Cristina M.,Catron, Nathaniel,Schmitt, Eric A.,Sanzgiri, Yeshwant D.
申请号：
AU2010336518
公开号：
AU2010336518A1
申请日:
2010.12.21
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
A pharmaceutical capsule comprises a shell having encapsulated therewithin a liquid solution of ABT-263 or a pharmaceutically acceptable salt thereof in a substantially non-ethanolic carrier that comprises as pharmaceutically acceptable excipients (a) at least one phospholipid, (b) at least one solubilizing agent for the at least one phospholipid, selected from the group consisting of glycols, glycerides and mixtures thereof, (c) at least one non-phospholipid surfactant and (d) at least one sulfur-containing antioxidant. The capsule is useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
