Computerized information acquisition and processing apparatus. In one embodiment, the apparatus includes an ingestible (e.g., swallowable) computerized device that includes a video apparatus, digital processor apparatus, and a wireless interface. A non-ingestible portion of the system communicates with the ingestible device via the wireless interface and, using computer software and algorithms, processes video data generated by the ingestible device relating to the intestinal tract of a living subject, so as to enhance the speed and/or accuracy of review by a physician or other individual. In one variant, the algorithmic processing by the non-ingestible apparatus includes one or more of: (i) color intensity analysis； (ii) artifact shape analysis； and/or (iii) inter-frame similarity analysis. In another variant, the ingestible device is configured to compress the data using the processor apparatus prior to transmission over the interface to conserve wireless bandwidth.
