<;P>;PROBLEM TO BE SOLVED: To provide a highly safe prophylactic or therapeutic agent for nonspecific hypersensitivity of mucosa (except for mucosa of the lower respiratory tract) suppressing nonspecific hypersensitivity of mucosa or nonspecific hypersensitivity accompanying nasal hypersensitivity caused by severe and/or chronic allergic rhinitis, and a prophylactic or therapeutic agent for nasal hypersensitivity caused by severe and/or chronic allergic rhinitis. <;P>;SOLUTION: The prophylactic or therapeutic agent for nonspecific hypersensitivity of mucosa (except for mucosa of the lower respiratory tract) contains at least one bacterium chosen from the group consisting of bifidobacterium, lactic acid bacterium and butyric acid bacterium. <;P>;COPYRIGHT: (C)2010,JPO&INPIT