A medicament comprising (I) brexpiprazole or a pharmaceutically acceptable salt thereof, and (II) nalmefene or a pharmaceutically acceptable salt thereof in combination, wherein brexpiprazole or a pharmaceutically acceptable salt thereof, and nalmefene or a pharmaceutically acceptable salt thereof are contained in a single preparation, or a pharmaceutical composition containing brexpiprazole or a pharmaceutically acceptable salt thereof and a pharmaceutical composition containing nalmefene or a pharmaceutically acceptable salt thereof are formulated for use in combination.一種藥物,其合併包含(I)布瑞哌唑(brexpiprazole)或其藥學上可接受之鹽類,及(II)納美芬(nalmefene)或其藥學上可接受之鹽類,其中布瑞哌唑或其藥學上可接受之鹽類及納美芬或其藥學上可接受之鹽類係包含於單一製劑中,或含有布瑞哌唑或其藥學上可接受之鹽類的藥學組成物及含有納美芬或其藥學上可接受之鹽類的藥學組成物係經調配以供合併使用。