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Rotavirus subunit vaccines and methods of making and use thereof
专利权人:
MERIAL INC.
发明人:
BEY RUSSELL F.,SIMONSON RANDY R.,SIRIGIREDDY KAMESH REDDY,HAUSE BENJAMIN MATTHEW
申请号:
NZ62828213
公开号:
NZ628282A
申请日:
2013.02.14
申请国别(地区):
NZ
年份:
2016
代理人:
摘要:
Disclosed is an immunological composition comprising: a) NSP4, VP4 and VP6 polypeptides; and b) a pharmaceutically or veterinary acceptable vehicle, diluent or excipient. Further disclosed is a method for producing the above composition comprising the steps of: (a) obtaining a biological sample from a non-human animal known or suspected of being infected with one or more types of rotavirus; (b) if infection status is not known, determining whether the animal is infected with rotavirus; (c) harvesting RNA from a biological sample previously obtained from the animal infected with the one or more type of rotavirus; (d) performing reverse transcriptase PCR using primers complementary to NSP4, VP4 and VP6 genes; (e) inserting the PCR product from step (d) into a suitable non-human expression vector; (f) placing the vector produced in step (e) into a suitable non-human host expression system; (g) harvesting the rotaviral polypeptides; and (h) adding to the rotaviral polypeptides any additional vaccine components, thereby producing the vaccine composition.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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