CO-CRYSTALS OF (S)-N-METHYL-8-(1-((2-METHYL-[4,5-BIPYRIMIDIN]-6-YL)AMINO)PROPAN-2-YL)QUINOLINE-4-CARBOXAMIDE AND DEUTERATED DERIVATIVES THEREOF AS DNA-PK INHIBITORS
The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.La présente invention concerne des compositions et des co-cristaux comprenant tous deux un composé de formule I ayant la structure : dans laquelle chacun des R1 et R2 représente H ou 2H et un agent de formation de co-cristaux choisi parmi lacide adipique, lacide citrique, lacide fumarique, lacide maléique, lacide succinique, ou lacide benzoïque. Linvention porte également sur des procédés de préparation et dutilisation de ceux-ci.
