AMERICAN CYANAMID COMPANY;IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
发明人:
PAUL, PREM S.,ZHANG, YANJIN
申请号：
CA2320359
公开号：
CA2320359C
申请日:
1999.02.08
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention provides a purified preparation containing, for example,at least one polypeptide selected from the group consisting of proteinsencoded by one or more open reading frames (ORF's) of an Iowa strain ofporcine reproductive and respiratory syndrome virus (PRRSV), antigenic regionsof such proteins which are at least 5 amino acids in length and whicheffectively protect a porcine host against a subsequent challenge with a PRRSVisolate, and combinations thereof in which amino acids non-essential forantigenicity may be conservatively substituted. The present invention alsoconcerns a vaccine comprising an effective amount of such a protein；antibodies which specifically bind to such a protein； methods of producing thesame； and methods of protecting a pig against a PRRSV, treating a pig infectedby a PRRSV, and detecting PRRSV in a pig.
